PIP3_345 -> ARF
PIP2_45 -> ARF
PI4K -> PIP2_45
PI5K -> PIP2_45
PTEN -> PIP2_45
PIP3_345 -> PIP2_45
PIP2_45 -> PIP2_45
PLC_B -|? PIP2_45
PLC_g -|? PIP2_45
PI3K -|? PIP2_45
alpha_sR -> Gbg_s
Gbg_s -| Gbg_s
Gas -? Gbg_s
Gas -> AC
Integrins -> AC
ECM -> AC
Gbg_i -> AC
Raf_Rest -? Raf_Rest
Raf_DeP -? Raf_Rest
Raf -| Raf_Rest
MKK3 -> p38
MKK6 -> p38
MKPs -| p38
PP2A -| p38
Sek1 -> p38
PLA2 -> AA
Rho -> RhoK
PIP2_34 -> Pix_Cool
PIP3_345 -> Pix_Cool
B_Parvin -> Pix_Cool
IL1_TNFR -> Trafs
Cas -> AND_34
CaM -> CaMK
PP2A -|? CaMK
CaMKK -> CaMK
alpha_qL -? alpha_qR
B_Arrestin -| alpha_qR
alpha_qR -? alpha_qR
Palpha_iR -? alpha_qR
Src -> Graf
Fak -> Graf
PKC -| RhoGDI
PIP2_45 -| RhoGDI
AA -| RhoGDI
alpha_1213L -? alpha_1213R
Palpha_1213R -? alpha_1213R
alpha_1213R -? alpha_1213R
B_Arrestin -| alpha_1213R
CaM -> CaMKK
PKA -|? CaMKK
Cas -> DOCK180
PIP3_345 -> DOCK180
Crk -> DOCK180
Cdc42 -> MLK2
Rac -> MLK2
SAPK -> MLK2
alpha_iR -> EGFR
PKC -? EGFR
alpha_1213R -> EGFR
Ca -> EGFR
alpha_qR -> EGFR
EGF -> EGFR
Trafs -> Trx
Stress -> Trx
Raf_Loc -? Raf_Loc
Raf_DeP -> Raf_Loc
Raf -| Raf_Loc
Ras -> Raf_Loc
alpha_sR -> Palpha_sR
GRK -> Palpha_sR
Gbg_q -| Gbg_q
Gaq -? Gbg_q
alpha_qR -> Gbg_q
DAG -> PKC
PKC -> PKC
PP2A -| PKC
Ca -> PKC
Trx -| PKC
AA -> PKC
PKC_primed -> PKC
alpha_sR -? alpha_sR
B_Arrestin -| alpha_sR
alpha_sL -? alpha_sR
Palpha_sR -? alpha_sR
PKA -| PLC_B
Gaq -? PLC_B
Gbg_i -> PLC_B
PLC_B -> PLC_B
Trafs -> Tpl2
ILK -> B_Parvin
PKA -> PKA
PP2A -| PKA
cAMP -> PKA
PDK1 -> PKA
CaMK -> Rap1
Rap1 -| Rap1
PKA -> Rap1
Gai -| Rap1
Src -> Rap1
cAMP -> Rap1
p190RhoGAP -| Rho
RhoGDI -| Rho
Graf -| Rho
PKA -| Rho
p115RhoGEF -> Rho
Rho -? Rho
alpha_iR -> Gai
alpha_sR -| Gai
PKA -> Gai
alpha_sL -> Gai
Gai -? Gai
Gbg_i -? Gai
RGS -| Gai
p90RSK -> PDK1
Src -> PDK1
CaM -> RGS
PIP3_345 -> RGS
Trafs -> GCK
GRK -> Palpha_1213R
alpha_1213R -> Palpha_1213R
Cas -> Cas
PTPPEST -| Cas
Src -> Cas
Fak -> Cas
Raf_Loc -> Raf
PAK -> Raf
RKIP -> Raf
Raf -? Raf
PKA -| Raf
Akt -| Raf
Erk -| Raf
Src -> Raf
Ras -? Raf
Cas -> Crk
PTPPEST -| Crk
Src -> Crk
Fak -> Crk
MKPs -| Erk
PP2A -| Erk
Erk -> Erk
Mek -> Erk
RhoK -> PI5K
PI5K -? PI5K
Src -> PI5K
PA -> PI5K
Talin -? PI5K
ARF -> PI5K
Fak -> PI5K
alpha_iR -? alpha_iR
B_Arrestin -| alpha_iR
alpha_iL -? alpha_iR
Palpha_iR -? alpha_iR
PKC -> RKIP
CaMK -> Tiam
PIP2_34 -> Tiam
PKC -> Tiam
Rap1 -> Tiam
PIP3_345 -> Tiam
Src -> Tiam
PIP2_45 -> Tiam
Ras -> Tiam
PDE4 -| cAMP
AC -> cAMP
cAMP -> cAMP
Ral -> RalBP1
Cdc42 -> MLK3
Rac -> MLK3
IL1_TNFR -> MLK3
TAK1 -> NIK
Nck -> NIK
Ca -> CaM
PKC -> PI4K
Gaq -> PI4K
Gai -> PI4K
Rho -> PI4K
ARF -> PI4K
PKC -| PTPPEST
PKA -| PTPPEST
Integrins -> PTPPEST
ECM -> PTPPEST
Palpha_1213R -> B_Arrestin
Palpha_qR -> B_Arrestin
Palpha_sR -> B_Arrestin
Palpha_iR -> B_Arrestin
DAG -> RasGRF_GRP
CaM -> RasGRF_GRP
Cdc42 -> RasGRF_GRP
Tab_12 -> TAK1
RhoK -> Myosin
CaM -> Myosin
PAK -> Myosin
ILK -> Myosin
MLCP -| Myosin
MLCK -> Myosin
Myosin -? Myosin
Grb2 -> PAK
PAK -> PAK
PKA -| PAK
Cdc42 -> PAK
Nck -> PAK
Akt -| PAK
Rac -> PAK
Src -> PAK
PTP1b -| PAK
CaMK -> PLA2
Ca -> PLA2
PIP3_345 -> PLA2
Erk -> PLA2
PIP2_45 -> PLA2
Cas -> Nck
EGFR -> Nck
PI4K -> PIP_4
PIP2_34 -> PIP_4
PI5K -| PIP_4
PTEN -> PIP_4
PIP_4 -? PIP_4
PI3K -| PIP_4
Gbg_1213 -? Csk
Gbg_q -? Csk
PKA -? Csk
Src -> Csk
Gbg_i -? Csk
Cbp -> Csk
SHP2 -| Csk
Fak -> Csk
EGFR -| PP2A
Src -> PI3K
EGFR -> PI3K
Gab1 -> PI3K
Gbg_i -> PI3K
Ras -> PI3K
Crk -> PI3K
Fak -> PI3K
p90RSK -| p90RSK
Erk -> p90RSK
PDK1 -> p90RSK
B_Arrestin -> PDE4
PKA -> PDE4
Erk -| PDE4
PAK -> Mek
Mekk2 -> Mek
Raf -> Mek
PP2A -| Mek
Tpl2 -> Mek
Mek -> Mek
Mekk1 -> Mek
Mekk3 -> Mek
CaM -> MLCK
PAK -| MLCK
PKA -| MLCK
Erk -> MLCK
WASP -> Arp_23
Arp_23 -> Actin
Myosin -> Actin
PP2A -? Integrins
ILK -? Integrins
Src -? Integrins
Integrins -? Integrins
ECM -? Integrins
Talin -? Integrins
Gab1 -> SHP2
ASK1 -> MKK6
MLK3 -> MKK6
PAK -> MKK6
TAK1 -> MKK6
TAO_12 -> MKK6
Tpl2 -> MKK6
Mekk4 -> MKK6
Raf_Rest -> Raf_DeP
Raf_Loc -| Raf_DeP
Raf_DeP -? Raf_DeP
PP2A -> Raf_DeP
Ga_1213 -> p115RhoGEF
PIP3_345 -> p115RhoGEF
PLD -> PA
PTEN -? Shc
Shc -| Shc
Src -> Shc
EGFR -> Shc
Fak -> Shc
Cas -> Src
alpha_sR -> Src
B_Arrestin -> Src
Gas -> Src
Csk -| Src
Gai -> Src
PTPa -> Src
Src -> Src
EGFR -> Src
Fak -> Src
PTP1b -> Src
Pix_Cool -> PTEN
Cdc42 -> PTEN
PTEN -> PTEN
Stress -> PTEN
Src -| PTEN
Rho -> PTEN
PI3K -> PTEN
Gbg_q -? Gaq
Gaq -? Gaq
PLC_B -| Gaq
alpha_qR -> Gaq
RGS -| Gaq
Grb2 -> WASP
PTPPEST -| WASP
Cdc42 -> WASP
Nck -> WASP
Src -> WASP
PIP2_45 -> WASP
Crk -? WASP
Fak -> WASP
alpha_iR -> Gbg_i
Gai -? Gbg_i
Gbg_i -| Gbg_i
MKK7 -> SAPK
MKPs -| SAPK
PP2A -| SAPK
SAPK -> SAPK
Sek1 -> SAPK
ASK1 -> MKK7
MLK3 -> MKK7
MLK2 -> MKK7
Mekk2 -> MKK7
Mekk1 -> MKK7
Mekk4 -> MKK7
MLK1 -> MKK7
Mekk3 -> MKK7
p120RasGAP -|? Ras
RasGRF_GRP -> Ras
Sos -> Ras
SHP2 -> Ras
DAG -> DGK
PKC -> DGK
Ca -> DGK
Src -> DGK
PA -> DGK
EGFR -> DGK
Src -> Grb2
Shc -> Grb2
EGFR -> Grb2
Fak -> Grb2
Stress -| PTP1b
EGFR -| PTP1b
EGF -> PTP1b
PIP2_45 -> IP3
PLC_B -> IP3
PLC_g -> IP3
Grb2 -> Mekk2
Mekk2 -| Mekk2
Src -> Mekk2
EGFR -> Mekk2
PLC_g -> Mekk2
PI3K -> Mekk2
alpha_iR -> RalGDS
alpha_sR -> RalGDS
PKC -| RalGDS
alpha_1213R -> RalGDS
B_Arrestin -> RalGDS
PIP3_345 -> RalGDS
alpha_qR -> RalGDS
Ras -| RalGDS
PDK1 -> RalGDS
Cdc42 -> MLK1
Rac -> MLK1
Gbg_1213 -? Ga_1213
Ga_1213 -? Ga_1213
alpha_1213R -> Ga_1213
p115RhoGEF -| Ga_1213
Src -| Talin
PIP2_45 -> Talin
Talin -? Talin
Gbg_s -? Gas
alpha_sR -> Gas
PKA -| Gas
Gas -? Gas
RGS -| Gas
Trx -> ASK1
Vinc -> Vinc
Actin -> Vinc
Src -> Vinc
PIP2_45 -| Vinc
Talin -> Vinc
CaM -> Ral
AND_34 -> Ral
RalGDS -> Ral
Stress -> TAO_12
Grb2 -> Gab1
PIP3_345 -> Gab1
EGFR -> Gab1
Gab1 -? Gab1
SHP2 -| Gab1
PIP3_345 -? PLC_g
Src -? PLC_g
PA -| PLC_g
EGFR -? PLC_g
AA -? PLC_g
Fak -? PLC_g
MLK3 -> Sek1
ASK1 -> Sek1
MLK2 -> Sek1
TAK1 -> Sek1
Mekk2 -> Sek1
Tpl2 -> Sek1
Mekk1 -> Sek1
Mekk4 -> Sek1
MLK1 -> Sek1
Mekk3 -> Sek1
PIP2_34 -> p120RasGAP
PIP3_345 -> p120RasGAP
Ca -> p120RasGAP
Src -| p120RasGAP
EGFR -> p120RasGAP
PIP2_45 -> p120RasGAP
SHP2 -| p120RasGAP
Fak -| p120RasGAP
Trafs -> Mekk3
Rac -> Mekk3
IL1_TNFR -> Mekk3
Gab1 -| Mekk3
PIP2_34 -> Akt
PP2A -| Akt
CaMKK -> Akt
Akt -? Akt
PIP3_345 -> Akt
ILK -> Akt
Src -> Akt
PDK1 -> Akt
Trafs -> Tab_12
p38 -| Tab_12
DGK -| DAG
DAG -> DAG
PIP2_45 -> DAG
PLC_B -> DAG
PLC_g -> DAG
Src -> Cbp
SHP2 -| Cbp
Grb2 -> Sos
Nck -> Sos
PIP3_345 -> Sos
Erk -| Sos
PIP2_45 -|? Sos
Crk -> Sos
Erk -> MKPs
SAPK -> MKPs
cAMP -> MKPs
p38 -> MKPs
alpha_iR -> Palpha_iR
GRK -> Palpha_iR
PIP3_345 -> ILK
GRK -> Palpha_qR
alpha_qR -> Palpha_qR
ASK1 -> MKK3
MLK3 -> MKK3
MLK2 -> MKK3
PAK -> MKK3
Mekk2 -> MKK3
TAK1 -> MKK3
TAO_12 -> MKK3
Tpl2 -> MKK3
Mekk4 -> MKK3
MLK1 -> MKK3
Mekk3 -> MKK3
p190RhoGAP -| Rac
Pix_Cool -> Rac
PAK -? Rac
RhoGDI -| Rac
Akt -|? Rac
Integrins -> Rac
DOCK180 -? Rac
RalBP1 -| Rac
Tiam -? Rac
Cdc42 -? Rac
RasGRF_GRP -? Rac
Rac -? Rac
ECM -> Rac
Gbg_i -? Rac
Gbg_1213 -> GRK
Gbg_s -> GRK
RKIP -| GRK
Gbg_q -> GRK
B_Arrestin -> GRK
Erk -| GRK
Src -> GRK
PIP2_45 -> GRK
Gbg_i -> GRK
ExtPump -| Ca
IP3R1 -> Ca
PKC -> PTPa
Grb2 -> Mekk1
NIK -> Mekk1
GCK -> Mekk1
Cdc42 -> Mekk1
Trafs -> Mekk1
Shc -> Mekk1
Rac -> Mekk1
Rho -> Mekk1
Ras -> Mekk1
PI4K -> PIP2_34
PIP2_34 -? PIP2_34
PI5K -| PIP2_34
PTEN -| PIP2_34
PI3K -> PIP2_34
CaM -? IP3R1
IP3 -? IP3R1
PKA -? IP3R1
PP2A -| IP3R1
Ca -? IP3R1
Gbg_i -> IP3R1
IP3R1 -? IP3R1
PTEN -| Fak
Src -> Fak
Integrins -> Fak
Talin -> Fak
Fak -> Fak
Gbg_1213 -| Gbg_1213
Ga_1213 -? Gbg_1213
alpha_1213R -> Gbg_1213
Cdc42 -> Mekk4
Rac -> Mekk4
p190RhoGAP ->? Cdc42
Pix_Cool -? Cdc42
PAK -> Cdc42
RalBP1 ->? Cdc42
Graf ->? Cdc42
RhoGDI -| Cdc42
Cdc42 -? Cdc42
Src -> Cdc42
Rac -| Cdc42
Gbg_i -> Cdc42
PKC -? PKC_primed
PKC_primed -? PKC_primed
PDK1 -> PKC_primed
PIP2_34 -> PIP3_345
PI5K -> PIP3_345
PTEN -| PIP3_345
PIP3_345 -> PIP3_345
PIP2_45 -> PIP3_345
PI3K -> PIP3_345
IL1_TNF -> IL1_TNFR
Actin -> PLD
PKC -> PLD
Cdc42 -> PLD
PIP3_345 -> PLD
Rac -> PLD
Rho -> PLD
PIP2_45 -> PLD
ARF -? PLD
p190RhoGAP -? p190RhoGAP
p120RasGAP -| p190RhoGAP
Src -> p190RhoGAP
Fak -> p190RhoGAP
RhoK -? MLCP
PAK -| MLCP
PKC -| MLCP
PKA -> MLCP
Raf -| MLCP
ILK -| MLCP
$AA: PLA2
$AC: ((Integrins & ECM) & (Gas & Gbg_i))
$AND_34: Cas
$ARF: (PIP2_45 | PIP3_345)
$ASK1: Trx
$Actin: (Arp_23 & Myosin)
$Akt: (((PDK1 & ((!Akt & (PIP2_34 | PIP3_345)) & (ILK & Src))) | (Akt & !PP2A)) | (CaMKK & ((!Akt & (ILK & Src)) & (PIP2_34 | PIP3_345))))
$Arp_23: WASP
$B_Arrestin: (((Palpha_sR | Palpha_iR) | Palpha_1213R) | Palpha_qR)
$B_Parvin: ILK
$Ca: (IP3R1 & !ExtPump)
$CaM: Ca
$CaMK: (CaMKK & CaM)
$CaMKK: CaM
$Cas: ((Src & Fak) & !(PTPPEST & Cas))
$Cbp: (Src & !SHP2)
$Cdc42: (((Cdc42 & (!RhoGDI & Pix_Cool)) & !(RhoGDI & Src)) | ((Pix_Cool & ((!Cdc42 & !Rac) & (PAK & Gbg_i))) & !(RhoGDI & Src)))
$Crk: ((Cas & (Src | Fak)) & !PTPPEST)
$Csk: ((Cbp & ((((Gbg_1213 | Gbg_q) | PKA) | Gbg_i) | ((((!Gbg_1213 & !Gbg_q) & !PKA) & !Gbg_i) & !SHP2))) | ((Fak & (Src & Cbp)) & !SHP2))
$DAG: ((((PLC_g & PIP2_45) & !(DGK & DAG)) | (DAG & !DGK)) | ((PLC_B & PIP2_45) & !(DGK & DAG)))
$DGK: (((PKC & DAG) | EGFR) | (Src & (Ca & PA)))
$DOCK180: (Crk & (PIP3_345 & Cas))
$EGFR: ((((alpha_qR & (PKC & Ca)) | (EGF & !PKC)) | (alpha_1213R & (PKC & Ca))) | (alpha_iR & (PKC & Ca)))
$Erk: (Mek | (Erk & !(PP2A | MKPs)))
$Fak: (((Integrins & Talin) & !(PTEN & Fak)) | ((Src & Fak) & !(PTEN & Fak)))
$GCK: Trafs
$GRK: ((((((Gbg_1213 & PIP2_45) & !(RKIP | Erk)) | ((Gbg_s & PIP2_45) & !(RKIP | Erk))) | ((B_Arrestin & Src) & !(RKIP | Erk))) | ((Gbg_i & PIP2_45) & !(RKIP | Erk))) | ((Gbg_q & PIP2_45) & !(RKIP | Erk)))
$Ga_1213: ((alpha_1213R & (!Gbg_1213 & !Ga_1213)) | (Ga_1213 & (Gbg_1213 & !p115RhoGEF)))
$Gab1: ((((Grb2 & EGFR) & !Gab1) & !SHP2) | ((Gab1 & (PIP3_345 & EGFR)) & !SHP2))
$Gai: (((alpha_iR & (!Gai & !Gbg_i)) | (PKA & (((!Gai & !alpha_sR) & !Gbg_i) & alpha_sL))) | (Gbg_i & (!RGS & Gai)))
$Gaq: (((alpha_qR & !Gaq) & !Gbg_q) | (Gaq & ((!PLC_B & !RGS) & Gbg_q)))
$Gas: ((alpha_sR & ((!Gas & !PKA) & !Gbg_s)) | (Gbg_s & (!RGS & Gas)))
$Gbg_1213: ((alpha_1213R & (!Ga_1213 & !Gbg_1213)) | Ga_1213)
$Gbg_i: (Gai | (alpha_iR & (!Gai & !Gbg_i)))
$Gbg_q: (Gaq | (alpha_qR & (!Gaq & !Gbg_q)))
$Gbg_s: ((alpha_sR & (!Gbg_s & !Gas)) | Gas)
$Graf: (Fak & Src)
$Grb2: (((Src & Fak) | EGFR) | Shc)
$IL1_TNFR: IL1_TNF
$ILK: PIP3_345
$IP3: ((PLC_g & PIP2_45) | (PLC_B & PIP2_45))
$IP3R1: (((PKA & !(((PP2A & IP3R1) | (Ca & (!IP3 & IP3R1))) | (CaM & (IP3R1 & Ca)))) | ((IP3 & Ca) & !((Ca & (!IP3 & IP3R1)) | (CaM & (IP3R1 & Ca))))) | (Gbg_i & !(((Ca & (!IP3 & IP3R1)) | (CaM & (IP3R1 & Ca))) | (IP3R1 & ((((!IP3 & !PKA) & !PP2A) & !Ca) & (CaM & Gbg_i))))))
$Integrins: ((((Talin & ((!ILK & !Integrins) & ECM)) | (Integrins & (!ILK & !Src))) | (PP2A & (((ILK & ECM) & Talin) & !Integrins))) | (Src & ((((!PP2A & !ILK) & !Integrins) & !ECM) & !Talin)))
$MKK3: ((((((((((Mekk2 & ASK1) | (MLK2 & ASK1)) | (MLK1 & ASK1)) | (Mekk4 & ASK1)) | (PAK & ASK1)) | (TAO_12 & ASK1)) | (TAK1 & ASK1)) | (Tpl2 & ASK1)) | (MLK3 & ASK1)) | (Mekk3 & ASK1))
$MKK6: ((((((TAO_12 & ASK1) | (PAK & ASK1)) | (Mekk4 & ASK1)) | (Tpl2 & ASK1)) | (MLK3 & ASK1)) | (TAK1 & ASK1))
$MKK7: (((((((Mekk3 & ASK1) | (Mekk4 & ASK1)) | (MLK3 & ASK1)) | (Mekk2 & ASK1)) | (MLK1 & ASK1)) | (MLK2 & ASK1)) | (Mekk1 & ASK1))
$MKPs: (((Erk & cAMP) | (SAPK & cAMP)) | (p38 & cAMP))
$MLCK: (((Erk & (!PAK & !PKA)) & !(PKA | PAK)) | ((CaM & (!PAK & !PKA)) & !(PKA | PAK)))
$MLCP: (((PKA & RhoK) & !(((Raf | PKC) | ILK) | PAK)) | !(((((RhoK | PAK) | PKC) | PKA) | Raf) | ILK))
$MLK1: (Cdc42 | Rac)
$MLK2: ((Cdc42 & SAPK) | (Rac & SAPK))
$MLK3: ((Rac | IL1_TNFR) | Cdc42)
$Mek: ((((((Tpl2 & !(PP2A & Mek)) | ((Mekk3 & Raf) & !(PP2A & Mek))) | ((Mekk2 & Raf) & !(PP2A & Mek))) | ((PAK & Tpl2) & !(PP2A & Mek))) | ((Raf & Tpl2) & !(PP2A & Mek))) | ((Mekk1 & Raf) & !(PP2A & Mek)))
$Mekk1: (((((((Cdc42 | (Grb2 & Shc)) | Rac) | (Rho & (Grb2 | Shc))) | (NIK & (Grb2 | Shc))) | Ras) | Trafs) | GCK)
$Mekk2: ((((PLC_g & (EGFR & !Mekk2)) | (PI3K & (!Mekk2 & EGFR))) | (Grb2 & (!Mekk2 & EGFR))) | (Src & (!Mekk2 & EGFR)))
$Mekk3: (((Rac & !Gab1) | (IL1_TNFR & !Gab1)) | (Trafs & !Gab1))
$Mekk4: (Cdc42 | Rac)
$Myosin: (((((((Myosin & !MLCP) & !(MLCP & Myosin)) | ((CaM & (MLCK & !Myosin)) & !(MLCP & Myosin))) | ((RhoK & (!Myosin | !MLCP)) & !(MLCP & Myosin))) | ((PAK & (!Myosin | !MLCP)) & !(MLCP & Myosin))) | ((MLCK & (CaM & !MLCP)) & !(MLCP & Myosin))) | ((ILK & (!Myosin | !MLCP)) & !(MLCP & Myosin)))
$NIK: (TAK1 | Nck)
$Nck: (Cas | EGFR)
$PA: PLD
$PAK: ((((Rac & ((Nck & !Akt) | Grb2)) & !PKA) | ((Cdc42 & ((Nck & !Akt) | Grb2)) & !PKA)) | (((Src & PAK) & (Cdc42 | Rac)) & !(PTP1b | PKA)))
$PDE4: ((B_Arrestin & !Erk) | (PKA & B_Arrestin))
$PDK1: (Src | p90RSK)
$PI3K: ((((((EGFR & Src) | Gab1) | Crk) | Gbg_i) | Ras) | Fak)
$PI4K: ((((ARF | Gai) | PKC) | Gaq) | Rho)
$PI5K: ((((RhoK | (Src & ((!PI5K & !Talin) & Fak))) | ARF) | PA) | (PI5K & Talin))
$PIP2_34: ((PI4K & (!PIP2_34 & PI3K)) | (PIP2_34 & (!PTEN & !PI5K)))
$PIP2_45: (((PI4K & PI5K) | PIP2_45) | (PTEN & PIP3_345))
$PIP3_345: (((PI3K & PIP2_45) & !(PTEN & PIP3_345)) | ((PI5K & PIP2_34) & !(PTEN & PIP3_345)))
$PIP_4: ((((PTEN & (!PIP_4 & PIP2_34)) & !((PI3K & PIP_4) | (PI5K & PIP_4))) | ((PIP_4 & (!PI5K & !PI3K)) & !((PI3K & PIP_4) | (PI5K & PIP_4)))) | ((PI4K & !PIP_4) & !((PI3K & PIP_4) | (PI5K & PIP_4))))
$PKA: (((PKA & cAMP) & !(PP2A & PKA)) | ((PDK1 & cAMP) & !(PP2A & PKA)))
$PKC: ((((DAG & (Ca & PKC_primed)) & !(Trx & PKC)) | ((AA & (Ca & PKC_primed)) & !(Trx & PKC))) | ((PKC & (!PP2A & !Trx)) & !(Trx & PKC)))
$PKC_primed: (((PKC_primed & !PKC) | (PKC & (PDK1 & !PKC_primed))) | (PDK1 & !PKC))
$PLA2: ((((PIP2_45 & (Erk & PIP3_345)) | (PIP3_345 & (CaMK & PIP2_45))) | (Erk & Ca)) | (CaMK & Ca))
$PLC_B: (Gaq | ((Gbg_i & PLC_B) & !(PKA & !Gaq)))
$PLC_g: ((((EGFR & PIP3_345) & !(PA & (AA & (!Src & !Fak)))) | (Fak & ((((!PIP3_345 & !EGFR) & !PA) & !AA) & Src))) | (Src & (PIP3_345 & Fak)))
$PLD: (((((Rho & ((Actin & (PIP3_345 | PIP2_45)) & !ARF)) | (Rac & ((Actin & (PIP3_345 | PIP2_45)) & !ARF))) | (ARF & (PIP2_45 | PIP3_345))) | (PKC & ((Actin & (PIP2_45 | PIP3_345)) & !ARF))) | (Cdc42 & ((Actin & (PIP3_345 | PIP2_45)) & !ARF)))
$PP2A: (!EGFR | !EGFR)
$PTEN: (((Pix_Cool & ((Cdc42 & Rho) & PI3K)) & !(Src & PTEN)) | (Stress & !(Src & PTEN)))
$PTP1b: (!(Stress | (EGFR & EGF)) | !((Stress | EGFR) | EGF))
$PTPPEST: ((Integrins & ECM) & !(PKA | PKC))
$PTPa: PKC
$Palpha_1213R: (alpha_1213R & GRK)
$Palpha_iR: (alpha_iR & GRK)
$Palpha_qR: (alpha_qR & GRK)
$Palpha_sR: (alpha_sR & GRK)
$Pix_Cool: ((PIP3_345 & B_Parvin) | (PIP2_34 & B_Parvin))
$RGS: (CaM & PIP3_345)
$RKIP: PKC
$Rac: (((((Pix_Cool & (((!PAK & ((((!RhoGDI & (ECM & Integrins)) & Cdc42) & !Rac) & ((!Tiam & !RasGRF_GRP) & !DOCK180))) | ((PAK & Gbg_i) & ((!Cdc42 & !Rac) & (ECM & Integrins)))) | (!Gbg_i & (((ECM & Integrins) & Cdc42) & !Rac)))) & !(RhoGDI & !PAK)) | ((Tiam & (Integrins & ECM)) & !(((p190RhoGAP & Rac) | (RhoGDI & !PAK)) | (RalBP1 & Rac)))) | ((DOCK180 & (Integrins & ECM)) & !(((p190RhoGAP & Rac) | (RhoGDI & !PAK)) | (RalBP1 & Rac)))) | ((RasGRF_GRP & (Integrins & ECM)) & !(((p190RhoGAP & Rac) | (RhoGDI & !PAK)) | (RalBP1 & Rac))))
$Raf: ((((Src & (!Raf & ((Raf_Loc & PAK) & RKIP))) | (Ras & Raf)) | (PAK & (((!Akt & !Erk) & !Ras) & Raf))) | (Raf & ((!PKA & !Akt) & !Erk)))
$Raf_DeP: ((PP2A & (Raf_Rest & !Raf_DeP)) | (Raf_DeP & !Raf_Loc))
$Raf_Loc: ((Raf_Loc & !Raf) | (Ras & (Raf_DeP & !Raf_Loc)))
$Raf_Rest: (((Raf_DeP & (!Raf_Rest & !Raf)) | (Raf_Rest & !Raf_DeP)) | !((Raf_Rest | Raf_DeP) | Raf))
$Ral: ((AND_34 | CaM) | RalGDS)
$RalBP1: Ral
$RalGDS: (((((alpha_1213R & B_Arrestin) & !(PKC | (Ras & (PDK1 & PIP3_345)))) | ((alpha_qR & B_Arrestin) & !(PKC | (Ras & (PDK1 & PIP3_345))))) | ((alpha_sR & B_Arrestin) & !(PKC | (Ras & (PDK1 & PIP3_345))))) | ((alpha_iR & B_Arrestin) & !(PKC | (Ras & (PDK1 & PIP3_345)))))
$Rap1: ((PKA & ((!Rap1 | !Gai) & (Src & cAMP))) | (CaMK & ((!Rap1 | !Gai) & (Src & cAMP))))
$Ras: ((SHP2 | RasGRF_GRP) | Sos)
$RasGRF_GRP: ((CaM & Cdc42) | (DAG & Cdc42))
$Rho: ((p115RhoGEF & (!RhoGDI & !Rho)) | (Rho & ((!p190RhoGAP & !Graf) & !PKA)))
$RhoGDI: (!((PKC | PIP2_45) | AA) | !((PKC | PIP2_45) | AA))
$RhoK: Rho
$SAPK: ((MKK7 & !((MKPs & SAPK) | (PP2A & SAPK))) | (Sek1 & !((MKPs & SAPK) | (PP2A & SAPK))))
$SHP2: Gab1
$Sek1: (((((((((MLK3 & ASK1) | (TAK1 & ASK1)) | (MLK2 & ASK1)) | (Mekk2 & ASK1)) | (MLK1 & ASK1)) | (Tpl2 & ASK1)) | (Mekk3 & ASK1)) | (Mekk1 & ASK1)) | (Mekk4 & ASK1))
$Shc: ((EGFR & (Src & Fak)) & !(Shc & (((PTEN & Src) & EGFR) & Fak)))
$Sos: ((Nck & (Crk & PIP3_345)) | ((Grb2 & PIP3_345) & !Erk))
$Src: ((((((((Fak & PTP1b) & !(Csk & Src)) | ((alpha_sR & B_Arrestin) & !(Csk & Src))) | ((Cas & PTP1b) & !(Csk & Src))) | (PTPa & !(Csk & Src))) | (EGFR & !(Csk & Src))) | ((Gai & B_Arrestin) & !(Csk & Src))) | ((Gas & B_Arrestin) & !(Csk & Src)))
$TAK1: Tab_12
$TAO_12: Stress
$Tab_12: (Trafs & !p38)
$Talin: ((PIP2_45 & !Talin) | (Talin & !Src))
$Tiam: (((PKC & ((PIP2_34 | PIP3_345) & ((Rap1 | PIP2_45) | Ras))) | (Src & ((PIP2_34 | PIP3_345) & ((Rap1 | PIP2_45) | Ras)))) | (CaMK & ((PIP2_34 | PIP3_345) & ((Rap1 | PIP2_45) | Ras))))
$Tpl2: Trafs
$Trafs: IL1_TNFR
$Trx: (Stress | Trafs)
$Vinc: ((Talin & Src) | (Actin & (!PIP2_45 & (Vinc & Talin))))
$WASP: ((((Src & ((Cdc42 & Crk) & ((Grb2 | Nck) | PIP2_45))) & !PTPPEST) | ((Cdc42 & (((Src | Fak) & (!PTPPEST & !Crk)) & ((Grb2 | Nck) | PIP2_45))) & !PTPPEST)) | ((Fak & (((Grb2 | Nck) | PIP2_45) & (Cdc42 & Crk))) & !PTPPEST))
$alpha_1213R: (((alpha_1213R & !(B_Arrestin & (Palpha_1213R | ((!alpha_1213L & !Palpha_1213R) & !alpha_1213R)))) | (alpha_1213L & !(B_Arrestin & (Palpha_1213R | ((!alpha_1213L & !Palpha_1213R) & !alpha_1213R))))) | ((Palpha_1213R & !B_Arrestin) & !(B_Arrestin & (Palpha_1213R | ((!alpha_1213L & !Palpha_1213R) & !alpha_1213R)))))
$alpha_iR: (((alpha_iL & !(B_Arrestin & (Palpha_iR | ((!alpha_iR & !alpha_iL) & !Palpha_iR)))) | ((Palpha_iR & !B_Arrestin) & !(B_Arrestin & (Palpha_iR | ((!alpha_iR & !alpha_iL) & !Palpha_iR))))) | (alpha_iR & !(B_Arrestin & (Palpha_iR | ((!alpha_iR & !alpha_iL) & !Palpha_iR)))))
$alpha_qR: (((alpha_qR & !(B_Arrestin & (Palpha_iR | ((!alpha_qL & !alpha_qR) & !Palpha_iR)))) | ((Palpha_iR & !B_Arrestin) & !(B_Arrestin & (Palpha_iR | ((!alpha_qL & !alpha_qR) & !Palpha_iR))))) | (alpha_qL & !(B_Arrestin & (Palpha_iR | ((!alpha_qL & !alpha_qR) & !Palpha_iR)))))
$alpha_sR: (((alpha_sL & !(B_Arrestin & (((!alpha_sR & !alpha_sL) & !Palpha_sR) | Palpha_sR))) | (alpha_sR & !(B_Arrestin & (((!alpha_sR & !alpha_sL) & !Palpha_sR) | Palpha_sR)))) | ((Palpha_sR & !B_Arrestin) & !(B_Arrestin & (((!alpha_sR & !alpha_sL) & !Palpha_sR) | Palpha_sR))))
$cAMP: ((cAMP & !PDE4) | (AC & !PDE4))
$p115RhoGEF: (Ga_1213 & PIP3_345)
$p120RasGAP: (((((PIP3_345 & !(Fak | Src)) | (EGFR & !((SHP2 | Fak) | Src))) | (Ca & !(Fak | Src))) | (PIP2_34 & !(Fak | Src))) | (PIP2_45 & !(Fak | Src)))
$p190RhoGAP: ((Src & ((!p190RhoGAP | !p120RasGAP) | Fak)) | (Fak & Src))
$p38: (((Sek1 & !(PP2A | MKPs)) | (MKK3 & !(PP2A | MKPs))) | (MKK6 & !(PP2A | MKPs)))
$p90RSK: (Erk & (PDK1 & !p90RSK))